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德斯莫伊德瘤初始治疗的演变
Alex J Bartholomew1, Kristen E Rhodin2, Laura Noteware2
1Department of Surgery, Duke University School of Medicine, Durham, NC, USA. alex.bartholomew@duke.edu.
Annals of surgical oncology
|August 12, 2024
概括
积极监测越来越多地成为desmoid瘤 (DTs) 的首选初始治疗方法,反映了传统手术的转变. 这种方法与当前的专家建议相一致,用于管理这些局部侵略性的非转移性纤维细胞瘤.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 临床研究 临床研究
背景情况:
- 德斯莫体瘤 (DTs) 是一种罕见的,局部具有攻击性的纤维细胞瘤.
- 从历史上看,前置手术切除是DTs的主要治疗方法.
- 目前的指导方针提倡积极监测作为首选的初始管理策略.
研究的目的:
- 分析随着时间的推移,desmoid瘤的初始管理策略的趋势.
- 评估积极监测和手术切除管理的患者的结果.
- 提供支持转向对数据技术的积极监控的数据.
主要方法:
- 对103名患有原发性desmoid瘤的患者 (2007-2020年) 的回顾性图表审查.
- 对初始管理策略的分析:切除,全身治疗,积极监测,冷.
- 评估无治疗生存期 (TFS),治疗时间 (TTT),无复发生存期 (RFS) 和复发时间.
主要成果:
- 手术切除率显著下降,从2018年之前的69.6%降至2018年后的29.2% (p < 0.001).
- 对于前期切除,5年无复发生存率为41.2%.
- 对于积极监测,两年无治疗生存率为66.7%,治疗中位时间为4个月.
结论:
- 观察到一个显著的过渡到主动监测的初始desmoid瘤管理.
- 这一趋势符合当代专家小组的建议和共识指南.
- 这项研究强调了在积极监测时代对瘤管理的关键指标.
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