在中国的复发性肺结核,2005年至2021年
Tao Li1,2,3,4, Bo Zhang5,6,7, Xin Du2,3
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
JAMA network open
|August 12, 2024
概括
复发性结核病 (TB) 是一个重大挑战,近一半的病例发生在治疗后两年内. 加强后续战略对于消除结核病的努力至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染病控制和控制传染病
背景情况:
- 复发性结核病 (TB) 是消除全球结核病的主要障碍.
- 长期观察患者是具有挑战性的,导致研究不足的复发模式.
研究的目的:
- 在中国调查复发性肺结核 (PTB) 的负担和模式.
- 确定与结核病复发相关的风险因素.
主要方法:
- 对中国PTB病例的回顾性队列研究 (2005-2021年).
- 根据疾病分类和时间分层的复发率的分析.
- 使用调整的危险比率识别风险因素.
主要成果:
- 观察到的整体PTB复发率为0.47/100人年.
- 二次性PTB的复发率最高 (0.48/100人年).
- 近一半 (48.9%) 的复发发生在前两年内;复发病例的比例在2015年至2021年间从4.7%增加到8.8%.
结论:
- 中国的PTB复发率很大,而且正在增加.
- 早期复发突显了治疗后随访对结核病消除的重要性.
- 有针对性的后续战略对于治疗复发性结核病至关重要.
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