在患有心脏代谢疾病的老年人中,抗炎饮食和痴呆症
Abigail Dove1, Michelle M Dunk1, Jiao Wang2,3
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|August 12, 2024
概括
抗炎饮食显著降低痴呆风险,并改善心脏代谢性疾病 (CMD) 患者的大脑健康. 这种饮食方法支持认知功能和大脑结构,提供对痴呆症的保护作用.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 炎症是心脏代谢疾病 (CMD) 和痴呆风险增加之间的联系.
- 抗炎饮食对CMD患者大脑和认知健康的影响尚不清楚.
研究的目的:
- 调查CMD状态,饮食炎症潜力和痴呆风险之间的关联.
- 通过联合效应分析,检查CMD,饮食和脑磁共振成像 (MRI) 测量之间的关系.
主要方法:
- 利用了来自英国生物库的84,342名没有痴呆症的老年人 (≥60岁) 的数据,随访时间长达15年.
- 使用饮食炎症指数 (DII) 评估基线CMD (糖尿病,心脏病,中风) 和饮食炎症潜力.
- 分析了与CMD和饮食有关的事件痴呆和脑MRI测量 (灰质体积,白质过强度).
主要成果:
- 患有心血管疾病和主导炎症饮食的人患痴呆症的风险增加了2.38倍 (HR, 2.38; 95% CI, 1.93-2.93).
- 那些患有心血管疾病和抗炎饮食的人与那些患有心血管疾病和抗炎饮食的人相比,患有心血管疾病的患者的痴呆风险降低了31% (HR,0.69;95% CI,0.55-0.88).
- 患有CMD和抗炎饮食的参与者在脑MRI上表现出较大的灰质体积和较小的白质超强度,相比于支持炎症饮食的参与者.
结论:
- 抗炎饮食与CMD患者痴呆的风险比率显著降低有关.
- 采用抗炎饮食可以支持大脑健康,由更大的灰质体积和减少白质超强度表明.
- 对抗炎症模式的饮食修改是减轻心脏代谢疾病患者群体痴呆风险的潜在策略.
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