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Updated: Jun 17, 2025

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
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基于综合生物信息学和孟德尔随机化,识别初级开角视眼中与视神经相关的生物标志物

Sijie Zhao1, Qing Dai1, Zixuan Rao1,2

  • 1Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.

Translational vision science & technology
|August 12, 2024
PubMed
概括

这项研究确定了三种新的生物标志物 (RAB8A,PRG3,SMAD3) 用于诊断初级开角青光眼 (POAG). 这些发现为POAG病原体和潜在的临床干预提供了新的见解.

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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