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囊性真菌菌菌的结果很差:一个多中心的临床病理学和分子病例系列

Christophe Bontoux^1,2,3,4, Marine Badrignans⁵, Sivem Afach

¹Department of Pathology, Cancer University Institute of Toulouse-Oncopole, Toulouse University Hospital, Toulouse, France.

The British journal of dermatology

|August 12, 2024

概括

囊性真菌菌菌 (pMF) 表明一种更具侵略性的疾病过程,具有更高的大细胞转化风险和降低生存率. 在真菌菌菌病 (MF) 中的组织学可能表明预后不佳,即使在早期阶段.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

菌根性菌病 (MF) 通常遵循惰的过程,但存在具有有限预后标记的攻击性形式.
突发性MF (pMF) 的孤立病例表明潜在的不良预后.

研究的目的:

划分状菌菌 (pMF) 的临床病理特征.
评估pMF的预后意义.

主要方法:

从2009年到2020年,对患有组织性 (pMF) 和非性 (NpMF) 的多发性肌痛患者进行了回顾性分析.
在pMF和NpMF队列之间的临床病理特征和结果的比较.

主要成果:

与NPMF相比,患有pMF的患者,特别是在诊断时 (pMFD),表现出更先进的疾病阶段和更高的大细胞转化率 (LCT).
诊断时的组织性瘤独立地与所有多发性肺炎患者和早期疾病患者的总生存期 (OS) 显著缩短有关.
pMFD与较高的LCT累积发病率相关.

结论:

pMF通常具有侵略性,具有高LCT风险和降低生存率的特征,即使在早期疾病阶段也是如此.
多发性肌痛中的组织性可能作为一个独立的不良预后指标.
病理学家应报告MF中的组织性,促使由于潜在的临床不充分识别,更密切地监测患者.

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