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基于4H-的类混合物中的抗氧化和抗微生物活性:合成和分子对接研究

Murali Krishna Vanga¹, Rambabu Bhukya¹, Vishnu Thumma²

¹Department of Chemistry, Osmania University, Hyderabad, 500007, Telangana, India.

Chemistry & biodiversity

|August 12, 2024

概括

新的印 Pyrimidine 混合物显示出强大的抗氧化和抗菌潜力. 化合物8g表现出卓越的抗氧化活性,而化合物10f表现出广泛的抗菌疗效,对细菌和真菌.

科学领域:

药用化学医学化学
有机合成有机合成
药理学药理学是指药理学的学科.

背景情况:

在生物活性分子中,和胺基支架很常见.
开发新的混合化合物对于发现新的治疗剂至关重要.
多组分反应为复杂的分子架构提供了高效的合成路径.

研究的目的:

为了合成基于4H-的新型印度尔-皮里米丁杂交物.
评估合成化合物的体外抗氧化和抗微生物活性.
通过分子对接研究来研究结合相互作用.

主要方法:

通过多元组件反应合成印-胺混合物.
使用IC50值进行体外抗氧化活性评估.
在体外对抗微生物查,针对格拉姆阳性,格拉姆阴性细菌和真菌菌株.
分子对接与NADPH氧化酶的晶体结构.

主要成果:

化合物8g和10a表现出强大的抗氧化活性,具有较低的IC50值.
几个化合物 (8a,8b,8d,10g) 与酸相比显示出显著的抗氧化抑制.
化合物10f对所有测试的细菌和真菌表现出异常广泛的抗菌活性.
化合物8e和8g对细菌菌株有活性,10g显示出强烈的抗真菌活性.
分子对接研究支持通过有利的结合相互作用观察到的活动.

结论:

合成的以4H-为基础的印度醇-皮里米丁杂交物具有显著的抗氧化和抗菌特性.
特定的衍生品,如8g和10f,是进一步药物开发的有希望的候选者.
该研究强调了这些杂交物作为传染病和与氧化压力相关的疾病的新疗法剂的潜力.

关键词:

4H - 烯 4H - 烯是一种抗微生物药物抗微生物药物抗氧化剂是一种抗氧化剂.印度尔 (Indole) 是一种皮里米丁是什么皮里米丁是什么

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