相关实验视频

Updated: Jun 17, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

宿主谱的基因组和功能决定因素在B组链球菌中

Chiara Crestani¹, Taya L Forde¹, John Bell²

¹Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom.

|August 12, 2024

概括

乙组链球菌 (GBS) 进化是由宿主适应形成的,特定的基因集群驱动宿主协会. 了解这些机制是防止病原体在动物和人类之间传播的关键.

科学领域:

微生物学微生物学
进化生物学进化生物学
基因组学就是基因组学.

背景情况:

乙组链球菌 (GBS) 是一种影响人类和动物健康的重要病原体,对公共健康和粮食安全构成风险.
进化途径和功能机制使GBS在新的宿主中适应和放大,促进溢出和溢出回流事件,尚未得到充分理解.

研究的目的:

为了研究进化机制和基因组特征,驱动宿主适应和宿主热带性在B组链球菌.
确定负责GBS与特定宿主物种的关联的遗传元素,并了解它们在物种间病原体传播中的作用.

主要方法:

分析了来自六大洲不同宿主物种的1,254个策划的B组链球菌基因组.
比较基因组学以确定与宿主相关的基因组特征,并评估不同GBS亚系的重组水平.

主要成果:

全球GBS种群包括宿主通用,宿主适应和宿主受限的亚系,其重组率各不相同.
GBS与主要宿主群体 (人类,牛,鱼) 的关联始终是由每个宿主单个辅助基因集群驱动的.
这些关键基因集群与同一个利基中的其他链球菌共享,并且对宿主热带性有重要作用.

结论:

细菌基因组在GBS中的可塑性有助于高风险克隆的出现,并促进适应新宿主.
跨物种基因传播在GBS的进化中起着至关重要的作用,使其能够在动物水库中扩散.
考虑动物宿主及其相关微生物群对于理解像GBS这样的多宿主病原体的进化和减轻动物传染风险至关重要.

更多相关视频

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

相关概念视频

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

Antibiotic Selection

Antibiotic Selection

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...