潜在的药物不相容性及其驱动因素 - 一个全医院的回顾性描述性研究
Nahyun Keum1, Junsang Yoo2, Sujeong Hur1
1Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea; AvoMD, Seoul, Republic of Korea.
International journal of medical informatics
|August 12, 2024
概括
药物不相容性在医院中很常见,通常在药物管理过程中发生. 这项研究分析了全医院的数据,以了解其流行率和促成因素,突出了某些患者群体的风险.
科学领域:
- 临床药房 临床药房
- 患者安全 患者安全
- 医疗信息学 医疗信息学
背景情况:
- 药物不相容是导致药物错误的重要原因,危及患者的安全.
- 之前关于药物不相容性的研究是有限的,主要集中在重症监护室 (ICU) 设置中.
- 在医院环境中全面了解药物不兼容性对于提高患者安全至关重要.
研究的目的:
- 调查药物不相容性的流行和机制.
- 分析全医院的处方和管理数据,以确定药物不兼容性模式.
- 扩大对药物不相容性的理解,超出ICU设置.
主要方法:
- 这是一项回顾性横截面研究,使用来自高等学术医院临床数据仓库的数据.
- 包括2021年1月1日至2021年5月31日的患者数据.
- 使用TrisselTM 2数据库识别潜在的药物对接触 (PC) 并评估不兼容性;用于风险因素分析的多变量后勤回归.
主要成果:
- 对30,359名患者和40,061例住院病人的分析显示,有25,108 (0.4%) 的不兼容药物对 (PC).
- 绝大多数不兼容PC (98.4%) 发生在药物管理阶段,而不是处方.
- 关键的驱动因素包括错误的顺序和管理因素,以及缺乏研究;男性性别,年龄较大,逗留时间较长,并发病率较高,以及医疗ICU入院增加了不兼容性风险.
结论:
- 药物不相容是临床环境中经常发生的情况,影响患者的安全.
- 对全医院数据的分析提供了对当前药物不兼容性状况的全面概述.
- 这些发现强调需要改进药物管理方案,以减轻不兼容性风险.
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