盖莱克-3和可溶性CD146在严重烧伤患者中识别心脏病损伤:基于生物标志物的方法
Louis Boutin1,2,3, Sabri Soussi4,5, Angèle Garcia Lavello1
1Department of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Cardiorenal medicine
|August 12, 2024
概括
心脏病综合征 (CRS) 在严重烧伤患者中很常见. 加勒-3 (Gal3) 和可溶性CD146 (sCD146) 水平可以帮助识别CRS,它们的联合使用提高了预测准确性.
科学领域:
- 发现生物标志物的发现.
- 关键护理医学 关键护理医学
- 烧伤伤害研究研究
背景情况:
- 严重的烧伤伤害经常导致急性损伤 (AKI) 和心肌损伤 (MI).
- AKI和MI的组合,称为心脏脏综合征 (CRS),是一个重大的临床挑战.
- 识别不同的心脏内表型对于有效的患者管理至关重要.
研究的目的:
- 评估加勒-3 (Gal3) 和可溶性CD146 (sCD146) 的发生和可靠性,作为在严重烧伤患者中识别CRS的生物标志物.
- 评估这些生物标志物的预测性能,以识别CRS.
主要方法:
- 一个单一中心的前性概念验证研究.
- 在入院后7天内,每天收集血样本.
- CRS是由AKI (KDIGO阶段≥1) 和MI (升高的hsTnT) 的存在来定义的.
主要成果:
- 在40名患者中,有38名 (95%) 患有CRS.
- 单独或与sCD146相结合的Gal3水平与CRS显著相关 (p < 0.001).
- 在入院时,Gal3和sCD146的组合 (D0) 显示了对CRS的更好的预测性能 (AUC = 0.81).
- 3水平预测了没有MI的AKI和没有AKI的MI,而sCD146显示了与CRS的不良关联.
结论:
- CRS是严重烧伤患者的常见和严重并发症.
- 在入院后的第一周内,Gal3水平与CRS有关.
- 结合Gal3和sCD146可提高该患者群体中CRS的预测能力.
- 需要进一步的研究来确认这些生物标志物对CRS识别的有用性.
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