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HIFU病变的组织学特征

Ian Rivens¹, Chaturika Jayadewa¹, Petros Mouratidis¹

¹Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

|August 12, 2024

概括

高强度聚焦超声波 (HIFU) 肝脏切除会导致明显的同心损伤区域. 与纯热效应相比,声腔和组织沸的存在创造了独特的中央病变形态.

科学领域:

医学成像和诊断医学成像和诊断
超声波技术的超声波技术
组织病理学组织病理学

背景情况:

高强度聚焦超声波 (HIFU) 为组织破坏提供了热除.
HIFU的生物学和组织学影响,包括声腔和组织沸,需要进一步的文件.
在体内大鼠肝脏模型为详细的HIFU暴露分析提供了一个平台.

研究的目的:

记录HIFU在老鼠肝脏中的生物和组织学影响.
描述HIFU造成的损伤区域,有或没有声腔/组织沸.
阐明HIFU诱导的热损伤的相似之处和差异.

主要方法:

在老鼠肝脏中利用了明确的HIFU暴露.
在暴露引起热损伤时与无声腔化/组织沸之间进行区分.
在组织学评估中采用了血素和欧 (H&E),红色皮克罗西里亚和免疫组织化学染色.
使用主动和被动方法检测到化活动.

主要成果:

鉴定出明显的同心损伤区域,有出血,细胞外空间增加和热固定细胞.
观察到独特的最中心的区域,当发生声洞化/沸时有不规则的洞.
在出血外围检测到裂开的caspase-3和Hsp70染色,表明炎症反应.
通过第7天在损伤中心注意到无细胞区域的形成.

结论:

HIFU诱导肝脏组织中特有的同心损伤区域.
声腔和组织沸显著改变了中央病变形态.
组织学分析显示HIFU切除后的炎症反应和细胞变化.

关键词:

这就是FUS FUS.这就是HIFU.高强度聚焦超声波外科手术声学化声学化肝脏组织学肝脏组织学热和沸造成的损伤.

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