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经过重复的异位捐献,导致日本男性捐献者严重缺铁

Takeshi Odajima¹, Nelson H Tsuno², Junko Iwasaki³

¹Japanese Red Cross Central Blood Institute, Tokyo, Japan.

|August 12, 2024

概括

频繁的异位献血者,特别是男性,由于献血器件的血液损失,显示出高铁缺乏率. 建议减少捐赠频率和改进设备,以减轻这种健康影响.

科学领域:

血液学血液学血液学
输血医学输血医学
营养科学营养科学

背景情况:

在日本的阿菲雷西斯捐献每年可提供多达24次血捐献,血小板法雷西斯计为2次.
目前的疏外术程序涉及转移初始的血液流动和机器电路中的残留血液的损失.
频繁的外出症对健康的影响,特别是铁的状况,需要研究.

研究的目的:

为了研究频繁的异位捐献对血清费里丁 (sFer) 水平的健康影响.
为了比较阿菲雷斯献血者和年龄相匹配的全血献血者之间的铁状况.
为了评估在连续的异位捐献期间sFer的变化.

主要方法:

这项研究招募了538名男性非献血者和538名年龄相匹配的男性全血献血者.
在不同年龄段的两组捐赠者之间比较了血清费里水平.
在四次连续的捐赠中,对19名阿菲雷斯捐赠者的小组进行了监测.

主要成果:

大约48%的重复献血的男性有缺铁 (sFer <26 ng/mL),而全血献血的男性有13.9%.
铁缺乏症在大多数年龄组中普遍存在,不包括青少年.
随访数据显示,在四个月的时间里,非瑞斯捐赠者血清费里水平逐渐下降.

结论:

亚流路中的血液损失和初始流量转移对频繁捐献者的铁缺乏有很大影响.
需要制造商改进的血液冲洗回流在非热症机器,在血小板法热症部分成功.
建议包括将血酶的频率降低到每年12次,并考虑口服铁补充剂.

关键词:

经常捐赠的捐赠.缺铁症是因为缺铁.血相结合酶 (Plasmapheresis) 是一种血小板转化是血小板的转化.血清费里氨酸的使用情况

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