血类固醇和城市成年人认知功能的纵向变化
May A Beydoun1, Hind A Beydoun2, Michael F Georgescu1
1Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
Journal of affective disorders
|August 12, 2024
概括
高水平的同类氨酸 (Hcy) 与城市成年人的认知能力下降有关. 性别和种族影响这些关联,影响注意力,记忆力和执行功能.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 同类氨酸 (Hcy) 水平与认知功能有着不一致的联系.
- 很少有研究在城市成年人群中调查了这种关联.
研究的目的:
- 在一个多元化的城市成年人群中,检查同类氨酸 (Hcy) 和随时间推移的认知表现之间的关系.
- 调查这种关联中的潜在的性别和种族特异性差异.
主要方法:
- 从生命周期 (HANDLS) 跨越多样性的社区健康老龄化研究中对数据的纵向分析.
- 测量基线和随访血液中的同型半氨酸 (Hcy) 水平.
- 用混合效应线性回归模型评估11个认知功能测试和分析.
主要成果:
- 较高的基线同型半氨酸 (Hcy) 与较差的注意力相关.
- 在男性中,高Hcy与视觉空间记忆的更快下降相关.
- 在非洲裔美国成年人中,随着时间的推移,增加Hcy与执行功能的更快下降有关.
结论:
- 在城市成年人中,高水平的homocysteine (Hcy) 和认知表现之间存在性别和种族特定的不良关联.
- 同类氨酸 (Hcy) 影响注意力,视觉空间记忆和执行功能.
- 还观察到Hcy,叶酸和维生素B-12之间的相互作用.
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