比较种族特定和种族中立的GLI螺旋计参考方程与印度参考方程
Subhabrata Moitra1, Ritabrata Mitra2, Saibal Moitra3
1Bagchi School of Public Health, Ahmedabad University, Ahmedabad, India.
Respiratory medicine
|August 12, 2024
概括
全球肺功能倡议 (GLI) 的螺旋测量方程在适用于印度人口时显示出显著的差异. 这凸显了在不同种族群体广泛使用之前需要评估全球肺功能模型的必要性.
科学领域:
- 肺部医学 肺部医学
- 医学统计 医学统计
背景情况:
- 全球肺功能倡议 (GLI) 的螺旋计参考方程越来越受欢迎.
- 它们对印度人口的适用性尚未被系统评估.
研究的目的:
- 评估印度成年人的种族特定和种族中立GLI螺旋计参考方程的适用性.
- 将GLI方程与广泛使用的印度参考方程进行比较.
主要方法:
- 对1123名健康的印度成年人 (≥18岁) 的螺旋测量测量的横截面分析.
- 使用GLI和印度方程计算参考值和z分数.
- 使用布兰德-阿尔特曼分析和弗里德曼测试评估异质性和差异.
主要成果:
- 在FVC (10.4%偏差) 和FEV1 (14.1%偏差) 的种族特定GLI和印度方程之间观察到显著的异质性.
- 种族中立的GLI方程式显示了类似的偏差 (FVC:9.8%,FEV1:13.8%).
- 与观察值相比,印度模型显示的差异很小 (FVC:0.10L,FEV1:0.05L),与GLI方程不同.
结论:
- 无论是种族特定的还是种族中立的GLI参考方程,都与印度特定方程有很大差异.
- 强调在不分青红白地在不同人群中应用之前,必须确定全球参考模型的适用性.
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