在肺移植接受者中,SARS-CoV-2幽默和细胞免疫的持续缺陷
Isabelle Etienne1, Delphine Kemlin2, Nicolas Gemander2
1Chest Department, Hôpital Universitaire de Bruxelles Erasme, Université Libre de Bruxelles, Brussels, Belgium; European Plotkin Institute for Vaccinology, Université Libre de Bruxelles, Brussels, Belgium.
概括
肺移植接受者 (LTRs) 与医疗保健工作者和养老院居民相比,对COVID-19变种的免疫力较弱. 持续的监测和预防对这个脆弱群体至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 移植 移植 移植 移植
背景情况:
- 肺移植接受者 (LTRs) 对严重的COVID-19的敏感性增加.
- 与一般人群相比,他们对SARS-CoV-2初级疫苗接种的免疫反应往往不理想.
- 在补充疫苗接种和自然感染后,LTRs的免疫力仍未得到充分证实.
研究的目的:
- 评估和比较LTRs中针对SARS-CoV-2变体的幽默和细胞免疫力.
- 为了评估LTRs随时间变化的免疫反应.
- 为了识别与COVID-19相关的LTRs中的持续性免疫缺陷.
主要方法:
- 在30个LTR中监测对SARS-CoV-2的幽默和细胞免疫力.
- 在LTRs,医疗保健工作者 (HCWs) 和养老院居民 (NHRs) 之间比较免疫反应.
- 评估2023年2月和5月对武汉,三角洲和XBB1.5SARS-CoV-2变种的反应.
主要成果:
- LTRs表明SARS-CoV-2结合和中和抗体水平显著降低.
- 与HCW和NHR相比,对SARS-CoV-2变体的干扰素马反应在LTR中显著较低.
- 在研究访问之间,幽默免疫力减弱,而细胞免疫力显示出更大的稳定性.
结论:
- 在肺移植接受者中,SARS-CoV-2免疫力的持续缺陷是明显的.
- 这些发现强调了对LTR持续监视和保护战略的需要.
- 该研究强调了LTRs对COVID-19及其变体的脆弱性.
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