相关实验视频

Updated: Jun 17, 2025

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

通过高强度超声波 (HIU) 增强的卵子转移素-酸复合物的免疫调节活性:一个结构功能关系研究研究

Tingting Tang¹, Thanh Ninh Le², Junhua Li³

¹School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; Faculty of Science, National University of Singapore, S14 Science Drive 2, Singapore 117542, Singapore.

International journal of biological macromolecules

|August 12, 2024

概括

高强度超声波 (HIU) 通过改变结构来增强蛋白质多复合体的形成和免疫调节活性. 最佳的HIU治疗持续时间是开发新型免疫调节剂的关键.

科学领域:

食品科学食品科学食品科学
生物技术是生物技术.
免疫学免疫学免疫学

背景情况:

蛋白质多复合物对健康益处至关重要.
优化它们的结构和功能对于有效的应用程序至关重要.
高强度超声波 (HIU) 为修改生物聚合物提供了一种新的方法.

研究的目的:

研究HIU对卵子转移素-黄素 (OVT-CA) 复合物的生理化学,形状和免疫调节性质的影响.
为了阐明在HIU治疗下OVT-CA复合物的结构功能关系.
探索HIU在开发增强免疫调节剂方面的潜力.

主要方法:

用高强度超声波 (HIU) 治疗OVT-CA复合体,持续时间和功率不同.
对粒子大小,分散,电负性,表面疏水性和二次结构 (β-sheet,α-helix) 的分析.
评估免疫调节活性,细胞膜亲和力,抗原识别和B细胞表位的可用性.

主要成果:

HIU减少了粒子大小,改善了分散,并增加了OVT-CA复合体的电子阴性.
HIU促进了OVT-CA结合,减少了相互作用时间并增加了移植度.
治疗HIU诱导结构变化 (例如α螺旋形成,增加水性) 和增强免疫调节活性.
治疗持续时间比功率更有影响力,在30分钟内获得最佳结果.

结论:

HIU有效地修改了OVT-CA复杂结构,增强了其免疫调节潜力.
由HIU引起的结构变化与改善的生物活性密切相关.
HIU为开发用于公共卫生和营养的基于蛋白质多的先进免疫调节剂提供了一种有前途的方法.

关键词:

基酸是一种基酸.高强度超声波的高强度超声波.免疫调节活性免疫调节活性分子构造的分子构造.卵子转移氨酸 (Ovotransferrin) 是一种

更多相关视频

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Published on: July 22, 2015

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Published on: May 8, 2012

相关概念视频

Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...