双甲暴露和怀孕期间的甲状腺功能障碍:系统性审查
Yaqi Zhu1, Keqin Liu1, Jinjin Guo1
1School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Reproductive toxicology (Elmsford, N.Y.)
|August 12, 2024
概括
怀孕期间接触 bisphenol A (BPA) 可能会破坏母亲的甲状腺激素平衡,可能会增加甲状腺功能障碍的风险. 需要进一步的研究来了解BPA.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 生殖医学 生殖医学
背景情况:
- 双A (BPA) 是一种广泛使用的化学物质,与各种健康问题有关.
- 怀孕涉及显著的荷尔蒙波动,使母亲的甲状腺特别脆弱.
- 怀孕期间甲状腺功能障碍会影响母亲和胎儿的健康.
研究的目的:
- 系统地审查和评估双甲 (BPA) 暴露与孕妇甲状腺功能之间的关联.
- 综合证据证明BPA如何影响妊娠期间关键的甲状腺激素.
- 为了确定BPA暴露对母亲甲状腺平衡的潜在风险.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Embase,Web of Science,Cochrane Library) 中进行全面的文献搜索.
- 包括11项原始研究,涉及6526名参与者,重点关注孕妇的BPA水平和甲状腺激素测量.
- 使用纽卡斯尔-太华尺度 (NOS) 和使用GRADE方法评估证据的包含研究的质量评估.
主要成果:
- 对11项研究的分析显示,由于BPA暴露,可能会对母亲甲状腺相关激素平衡产生干扰.
- 有证据表明,怀孕期间BPA暴露可能会增加与甲状腺功能过高症相关的甲状腺功能过高风险.
- 检查的激素包括TSH,TT3,TT4,FT3,FT4及其比例.
结论:
- 怀孕期间的双甲暴露可能会对母亲的甲状腺功能产生负面影响.
- 研究结果表明,BPA与孕妇甲状腺功能障碍症风险增加之间存在潜在联系.
- 需要进一步的研究来阐明机制,并确认BPA在怀孕期间对甲状腺健康的影响.
关键词:
BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA孕产妇暴露的母亲暴露.怀孕 怀孕 怀孕 怀孕系统性审查 系统性审查甲状腺功能 甲状腺功能甲状腺激素 甲状腺激素更多相关视频
04:14Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
798
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
2.6K
相关概念视频
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Functions of Thyroid Hormones
2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
Pathophysiology of Diabetes
911
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
911
Synthesis and Regulation of Thyroid Hormones
4.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.4K
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K
