在喘-Copd重叠的实验体内模型中,光生物调节的效果
Marina Bertoni Guerra1, Kelly Gomes Santana1, Marcos Momolli1
1Post Graduate Program in Medicine-Biophotonic, University Nove de Julho (UNINOVE), São Paulo, Brazil.
Journal of biophotonics
|August 12, 2024
概括
使用激光疗法进行光生物调制 (PBM) 可能有助于控制喘和COPD (ACO) 中的呼吸道炎症. 这项研究表明,PBM在体外ACO模型中减少了关键的炎症标志物.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统医学 呼吸系统医学
- 炎症研究 炎症研究
背景情况:
- 呼吸道炎症是喘和慢性阻塞性肺病 (ACO) 的标志.
- 目前用于ACO炎症的治疗方法存在局限性.
- 需要新的治疗策略来调节炎症级联.
研究的目的:
- 在ACO的体外模型中研究光生物调制 (PBM) 治疗的疗效.
- 评估激光照射对暴露于香烟烟雾提取物 (CSE) 和室内灰尘虫 (HDM) 的支气管上皮细胞炎症标记物的影响.
主要方法:
- 在体外ACO模型中利用了人类支气管上皮细胞 (BEAS-2B).
- 这些组包括对照组,甲治疗,单独激光照射,CSE+HDM刺激,CSE+HDM用甲,以及CSE+HDM用激光照射.
- 在24小时后量化细胞因子水平 (TNF-α,IL-1β,IL-6,IL-4,IL-5,IL-13,IL-17,IL-21,IL-23,IL-10,IFN-γ).
主要成果:
- 激光照射的ACO细胞显示,促炎性细胞因子 (TNF-α,IL-1β,IL-6,IL-17等) 的显著减少. ) 的情况.
- 在激光治疗组中观察到抗炎细胞因子 (IL-10) 和免疫调节细胞因子 (IFN-γ) 的增加.
- 与非刺激的ACO模型相比,光生物调节显示出明显的免疫调节效应.
结论:
- 光生物调制 (PBM) 疗法在ACO的体外模型中有效调节炎症过程.
- 激光疗法在ACO中提供了管理呼吸道炎症的潜在治疗选择.
- 需要进一步的研究来探索PBM在呼吸道疾病中的临床适用性.
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
192
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
192
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Asthma: Pathogenesis and Management
378
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
378
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K