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轻度至中度马类喘的马和健康的对照群之间通过振荡计测量肺功能差异
Chiara Maria Lo Feudo1, Francesco Ferrucci1, Davide Bizzotto2
1Equine Sports Medicine Laboratory "Franco Tradati", Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
Equine veterinary journal
|August 12, 2024
概括
振荡计可以通过测量肺功能来帮助诊断轻度至中度马类喘 (MEA). 反应力的频率依赖 (Xrs) 在健康的马和受MEA影响的马之间显示出显著的差异.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 肺部生理学 肺部生理学
- 马的健康 马的健康
背景情况:
- 轻度至中度的马类喘 (MEA) 诊断依赖于内镜检查,支气管支气管洗液 (BALf) 细胞学和间接的膜压力测量.
- 振荡计是一种非侵入性肺功能测试,有可能用于MEA诊断,但其在检测亚临床呼吸道阻塞方面的有效性需要进一步评估.
研究的目的:
- 为了比较通过振荡计在健康的马匹获得的肺功能参数与那些有MEA.
- 为了确定振荡计能否区分健康和受MEA影响的马体受试者.
主要方法:
- 一项前性病例控制研究,涉及37匹马,根据临床症状和诊断程序将其分类为健康或受MEA影响的马.
- 在2-6 Hz的频率范围内对所有马进行了振荡计,分析了电阻 (Rrs) 和反应率 (Xrs) 参数.
- 统计分析包括重复测量双向ANOVA,t测试和接收器操作特征 (ROC) 曲线分析以确定诊断截止值.
主要成果:
- 在健康组和MEA组之间,没有发现总体抵抗力 (Rrs) 或反应力 (Xrs) 的显著差异.
- 在两组之间观察到整个呼吸和吸入反应率 (Xrs) 的频率依赖的显著差异 (分别p < 0.05和p < 0.01).
- 吸入性Xrs的频率依赖确定了-0.06cmH2O/L/s的截止值,MEA诊断的灵敏度为86.4%,特异性为66.7%.
结论:
- 振荡计,特别是对反应率 (Xrs) 频率依赖性的分析,显示出作为轻度至中度马类喘 (MEA) 的非侵入性诊断工具的前景.
- 需要进一步研究更大的样本大小和对照组的全面诊断标准.
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