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Updated: May 8, 2026

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单细胞长读向测序揭示了卵巢癌的转录变异

Ashley Byrne1, Daniel Le1, Kostianna Sereti2

  • 1Department of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.

Nature communications
|August 12, 2024
PubMed
概括

新的长读测序 (scTaILoR-seq) 可以准确地识别单细胞中的RNA异型. 这种方法增强了用于卵巢癌研究的转录检测,揭示了与替代RNA结构的变异关联.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...