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Updated: Jun 17, 2025

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
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SRF SUMOylation调节了光滑肌肉的表型切换和血管重塑

Yue Xu1,2, Haifeng Zhang1, Yuxin Chen3

  • 1Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Nature communications
|August 12, 2024
PubMed
概括

血管光滑肌细胞 (VSMC) 中的Senp1缺乏会增加SUMOylatedSRF,促进心血管疾病. 准SRF-ELK复合体可能为治疗心血管疾病 (CVD) 提供新的治疗策略.

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