新辅助化疗对乳腺癌患者术后免疫功能的影响:一种倾向性得分匹配的回顾性研究
Qi-Hua Jiang1, Hai Hu1,2, Zhi-Hong Xu1
1Department of Breast Surgery, The Third Hospital of Nanchang, No. 2, Xiangshan South Road, Xi hu District, Nanchang City, 330008, Jiangxi Province, China.
Scientific reports
|August 12, 2024
概括
新辅助化学疗法新辅助化学疗法
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 手术瘤学手术瘤学
背景情况:
- 新辅助化疗是乳腺癌的常见治疗方法.
- 它对外科手术期间免疫功能的影响需要进一步调查.
- 了解免疫变化对于优化患者的治疗结果至关重要.
研究的目的:
- 评估新辅助化疗对特定免疫细胞群 (CD3 +,CD4 +,CD8 +,NK细胞) 和乳腺癌患者在术后期间的CD4 + / CD8 +比率的影响.
- 根据化疗敏感性来区分免疫反应.
主要方法:
- 对2020年1月至2022年12月期间接受手术的乳腺癌患者的回顾性评估.
- 倾向性得分匹配,将接受新辅助化疗的患者与没有接受化疗的患者进行比较.
- 在术前和术后的时间点 (1日和7日) 分析免疫细胞比例和CD4+/CD8+比率.
主要成果:
- 在全新辅助化疗和非化疗组之间或在化疗敏感患者中,没有观察到免疫细胞比例或CD4+/CD8+比率的显著差异.
- 与对照组相比,化学疗法不敏感的患者显示CD4+和NK细胞的比例明显较低,CD4+/CD8+比率较低,在所有测量时间点中.
- 这些发现表明,基于治疗反应,新辅助化疗对免疫功能的影响有所差异.
结论:
- 新辅助化疗可能会损害化学疗法不敏感的乳腺癌患者的术后免疫功能.
- 在接受新辅助化疗的化疗敏感患者中,免疫功能似乎被保留.
- 根据预测的敏感性量身定制新辅助疗法可以减轻潜在的免疫抑制.
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