甲状腺癌的风险和哈西莫托甲状腺炎的性别差异,一个元分析
Yali Le1, Chenchen Geng2, Xiaoqian Gao2
1Health Management Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, Shandong, PR China.
BMC endocrine disorders
|August 12, 2024
概括
哈西莫托的甲状腺炎 (HT) 显著增加了甲状腺癌 (TC) 的风险. 虽然HT患者的TC患病率在女性中略低于男性,但这种差异在统计学上并不显著,这凸显了定期HT患者审查的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 甲状腺癌 (TC) 的患病率正在全球上升.
- 越来越多的证据将哈西莫托氏甲状腺炎 (HT) 与TC风险增加联系起来.
- 在HT和TC之间存在的性别差异需要进一步调查.
研究的目的:
- 系统地审查和元分析HT患者的TC风险.
- 澄清HT患者中TC患病率的潜在性别差异.
主要方法:
- 在主要的科学数据库 (PubMed,Cochrane Library,EMBASE,Web of Science) 进行了全面的系统搜索.
- 包括26项回顾性研究,数据由两位作者独立提取.
- 聚合几率比率 (OR) 和95%置信区间 (CI) 使用STATA计算,并进行了补充性特异分析.
主要成果:
- 对26项研究 (2,845项记录) 的元分析证实了HT和TC之间的显著关联 (OR:2.22,95%CI:1.85-2.67).
- 在HT患者中,TC的患病率在女性中为0.31 (95%CI:0.17-0.45),在男性中为0.37 (95%CI:0.21-0.53).
- 在HT患者中观察到的TC患病率的基于性别的差异在统计学上并不显著.
结论:
- 哈西莫托的甲状腺炎与患甲状腺癌的风险增加有关.
- 对被诊断患有HT的患者进行定期临床检查对早期检测和管理具有临床意义.
- 进一步的研究可能是有必要的,以充分阐明在HT人群中TC风险的性别差异的细微差别.
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