白天小睡和帕金森病的发病率:一个前性队列研究,使用孟德尔随机化
Fabin Lin1,2,3,4,5, Yisen Shi1,2,3,4, Wenjing Song1,2,3,4
1Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
BMC medicine
|August 12, 2024
概括
白天小睡,尤其是频繁或长时间的小睡,与更高的帕金森病 (PD) 风险有关. 然而,门德尔的随机化分析没有证实午睡频率与PD之间的因果关系. 需要进一步的研究来澄清这种关联.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 白天小睡和帕金森病 (PD) 风险之间的关系尚未得到充分理解.
- 之前的前性研究对这种关联提供了有限的证据.
- 调查潜在的因果关系对于理解PD病因学至关重要.
研究的目的:
- 检查白天小睡频率和持续时间与帕金森病发病率之间的关联.
- 使用孟德尔随机化 (MR) 分析,探索白天小睡和PD风险之间的潜在因果关系.
- 评估系统性免疫炎症指数 (SII) 在午睡-PD关联中的调解作用.
主要方法:
- 一项针对393302名参与者进行的前性队列研究,使用加速度计测量了78141名个体的午睡数据.
- 考克斯比例危险回归分析小睡频率/持续时间和PD风险.
- 对SII进行调解分析和对因果关系进行双样本门德尔随机化 (MR) 分析.
主要成果:
- 与从未/很少午睡的人相比,有时 (HR, 1.13) 或通常 (HR, 1.33) 午睡的参与者观察到PD风险增加.
- 睡眠时间超过1小时与PD风险显著增加有关 (HR,1.54).
- MR 分析没有发现小睡频率与PD 风险之间存在显著的因果关系; SII 发挥了调解作用.
结论:
- 增加白天小睡的频率和持续时间与更高的PD风险有关.
- 通过MR分析,睡眠频率和PD风险之间没有建立起因果关系.
- 建议进行较大的基于GWAS的队列和MR研究,以进一步调查潜在的因果关系.
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