嵌入在热凝中的交叉连接混合纳米粒子,用于持续向内耳共递送
Neeraj S Thakur1, Iulia Rus1, Aidan Herbert2
1Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, 1110 North Stonewall Avenue, Oklahoma City, OK, 73117, USA.
Journal of nanobiotechnology
|August 12, 2024
概括
这项研究开发了一种新的纳米粒子水凝系统,用于治疗药物诱导的耳毒性. 该配方有效地保护细胞和斑马鱼免受西斯普拉丁诱导的损伤,为预防听力损失提供了一个有前途的局部输送方法.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 耳毒性研究研究 耳毒性研究
背景情况:
- 治疗引起的耳毒性和听力损失是化学疗法和抗生素的重大问题.
- 对内耳的局部输送是可取的,用于预防或早期治疗耳毒性.
研究的目的:
- 为了研究一种用于治疗药物诱导的耳毒性,通过耳传递的新型,持续的纳米配方.
- 为了评估Flunarizine (FL) 和Honokiol (HK) 在热反应性水凝中用于耳毒性保护的同时交付.
主要方法:
- 合成FL和HK装载的交联混合纳米粒子 (cHy-NPs) 使用质量设计方法 (DoE-CCD).
- 在HEI-OC1细胞和体内斑马鱼模型中评估了对西斯的细胞保护作用.
- 通过将cHy-NPs嵌入热凝水凝中,开发出最终的纳米配方,并描述其稳定性和药物释放.
主要成果:
- 结合FL和HK显示了增强的细胞毒性保护作用.
- 成功合成了具有高封装效率和负载的稳定纳米粒子.
- 纳米配方在体外显著降低了caspase 3/7的激活,并在体内保护了神经巨毛细胞.
- 热凝配方提供持续释放FL和HK至少一个月.
结论:
- 嵌入在热凝中的稳定,新型纳米配方已成功开发用于局部内耳输送.
- 这种配方显示出对抗治疗诱导或药物诱导的耳毒性的潜力.
- 在热凝中通过cHy-NPs同时输送FL和HK,为预防耳毒性提供了一个有前途的策略.
关键词:
人工智能图像分析图像分析中心复合设计设计深度学习模型深度学习模型药物诱导的中毒性 药物诱导的中毒性听力损失 听力损失当地的药物配送服务.长期药物输送 长期药物输送耳部保护剂 耳部保护剂通过设计的质量方法.氧化还原平衡 (redox homeostasis) 是一种斑马鱼模型模型更多相关视频
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