在阿玛米棘鼠 (Tokudaia osimensis) 中,胸内囊性肉瘤的病理特征
Kazuhiro Kojima1, James K Chambers1, Madoka Yoshizawa2
1Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
The Journal of veterinary medical science
|August 13, 2024
概括
在一个阿玛米棘鼠中诊断出了一种罕见的囊细胞肉瘤. 这种侵袭性癌症导致体重减轻和呼吸困难,最终导致动物死亡.
科学领域:
- 兽医病理学 兽医病理学
- 比較瘤學 的相關搜尋
- 动物新陈代谢 动物新陈代谢
背景情况:
- 阿玛米棘鼠是一种独特的动物物种.
- 新生病可以显著影响动物卫生和动物园环境中的动物福利.
- 囊性肉瘤是一种具有骨髓性起源的侵袭性恶性瘤.
研究的目的:
- 为了报告一个阿玛米刺状老鼠的囊性肉瘤病例.
- 描述瘤的组织病理学和免疫组织化学特征.
- 讨论死亡的潜在原因.
主要方法:
- 尸体解剖和组织病理学检查组织.
- 针对特定标记物的免疫组织化学染色 (vimentin,Iba-1,CD204,E-cadherin,S100).
主要成果:
- 一只4岁9个月的阿玛米棘鼠出现了厌食症,体重减轻和呼吸困扰.
- 在膜,胸壁,心脏和肺部发现了新形成的组织.
- 在组织学上,瘤由大圆到多边形的瘤细胞和多核巨细胞组成.
- 在腹部淋巴结中存在转移性病变.
- 免疫组织化学检测显示对维门丁,Iba-1和CD204的阳性,对E-cadherin和S100的负性.
- 瘤被诊断为囊细胞肉瘤.
结论:
- 囊性肉瘤是阿玛米棘状老鼠呈现类似临床症状的潜在诊断.
- 肺部的瘤压缩可能导致呼吸衰竭和死亡.
- 这一案例凸显了考虑异国动物罕见恶性瘤的重要性.
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