开发和优化用于局部应用的甲基马微乳液:配方特性和通过皮肤透
Anayatollah Salimi1,2, Hadis Hoseinzadeh2, Saeed Mohammad Soleymani3,4
1Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Journal of cosmetic dermatology
|August 13, 2024
概括
这项研究开发了一种优化的甲基马微乳液,用于局部治疗乳瘤. 这种新型配方显示出安全有效的皮肤亮化应用的潜力.
科学领域:
- 皮肤病学和制药科学 皮肤病学和制药科学
- 纳米技术在药物输送中的应用
- 化品 化品 化品
背景情况:
- 甲基马,一种抗甲状腺药物,在局部治疗乳腺瘤治疗中显示出有前途.
- 目前治疗梅拉斯马的方法往往有局限性,需要新的方法.
- 微乳液为局部药物提供了增强的输送和稳定性.
研究的目的:
- 开发和优化用于局部瘤治疗的甲基马微乳液.
- 描述微乳液的物理化学特性和皮肤透.
- 建立一个安全有效的新方法来治疗瘤.
主要方法:
- 含有3%甲基马的微乳液是使用表面活性剂 (Tween 80,Span 20),二醇和油酸-转醇P油相制成的.
- 配方的特点是滴滴大小,稳定性和粘度.
- 实验室皮肤透研究使用老鼠皮肤模型进行.
主要成果:
- 优化的微乳液呈现出7.06和28.13纳米之间的液滴大小和120-254cP的粘度.
- 滴滴大小,粘度和膜释放被确定为影响配方性能的关键独立变量.
- 通过老鼠皮肤确定了透性参数 (Jss,p,Tlag,Dapp) 以获得最佳配方.
结论:
- 微乳液特性受到表面活性剂与表面活性剂比率,水含量和油含量的影响.
- 成功开发了一种具有高表面活性剂与表面活性剂比率和低水/油含量的最佳配方.
- 这种优化的甲基马微乳液具有商业化和制造用于治疗梅拉斯马的潜力.
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