影响脏功能的治疗作为儿童癌症幸存者的膜心脏病风险因素:DCCSS-LATER研究
Bente M Houtman1,2, Iris Walraven3, Livia Kapusta4,5
1Radboudumc Center of Expertise for Cancer Survivorship, Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
经过脊髓切除术的儿童癌症幸存者面临更高的膜心脏病 (VHD) 风险. 这项研究强调了切除术和VHD在这个人群中的显著关联.
科学领域:
- 心脏病学 心脏病学
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
背景情况:
- 儿童癌症幸存者 (CCS) 可能面临长期的健康风险.
- 心脏病 (VHD) 是癌症治疗的潜在后期影响.
- 影响脏功能的治疗对VHD风险的影响在CCS中尚未得到充分证实.
研究的目的:
- 研究切除术或涉及脏的放射治疗与儿童癌症幸存者的VHD风险之间的关联.
- 为了比较VHD发病率在CCS接受治疗影响脏功能与那些没有接受治疗的人.
主要方法:
- 利用了DCCSS-LATER队列,包括1963年至2002年间诊断的6165名5年CCS患者.
- 通过问卷和验证的医疗记录评估了症状性VHD.
- 使用格雷测试进行累积发病率比较和多变量考克斯比例危险模型进行风险因素分析.
主要成果:
- 该研究包括5286名CCS患者,随访时间中位数为22年.
- 到40岁时,CCS患者的VHD累积发病率显著更高,这些患者接受了影响脏功能的治疗 (2.7%),而不是 (0.4%).
- 切除术与VHD有很强的关联 (危险比率8.6,95% CI 3.1-24.1).
结论:
- 切除术是儿童癌症幸存者中膜心脏病的重要危险因素.
- 需要进一步的研究来探索VHD查对经过脊髓切除术的CCS的潜在益处.
- 这些发现强调了这种脆弱人群中长期心血管监测的重要性.
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