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机械多参数优化和大规模的应用在体外到体外 药理动力学 对小分子治疗项目的相关性

Fabio Broccatelli1, Vijayabhaskar Veeravalli1, Daniel Cashion1

  • 1Bristol-Myers Squibb Company, San Diego, California 92121, United States.

Molecular pharmaceutics
|August 13, 2024
PubMed
概括

机械多参数优化 (MPO) 使用生理学相关的模型来预测药物特性,减少药物发现中的偏差. 这种方法有效地优先考虑临床试验中的化合物,并尽量减少在体内进行广泛测试的需要.

关键词:
领先优化优化 领先优化机器学习是机器学习.多个参数优化的优化.药物动力学 药物动力学

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