与60岁及以上良性前列腺增生患者同时患前列腺癌相关的因素
Mengdi Wu1,2, Kun Zheng2,3, Yanjie Cao1
1Department of Geriatrics, Air Force Medical Center, Beijing, China.
概括
这项研究确定了预测60岁以上男性患前列腺癌的关键因素. 更高的年龄,无机,球蛋白和LDL胆固醇,以及较低的自由前列腺特异性抗原 (fPSA) /总前列腺特异性抗原 (tPSA) 比率和血清,都与前列腺癌风险有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 前列腺增生 (BPH) 和前列腺癌 (PCa) 在老年男性中很常见.
- 雄激素受体涉及到BPH和PCa.
- 有效的健康管理需要在老年男性中确定PCa预测因子.
研究的目的:
- 在60岁及以上的男性中确定与前列腺癌 (PCa) 相关的因素.
- 加强对有PCa风险的老年男性的健康管理策略.
- 在这个人口群体中探索BPH和PCa之间的关系.
主要方法:
- 利用"前列腺癌早期预警数据集"进行分析.
- 在变量选择中使用LASSO回归.
- 使用多因素后勤阶段回归构建了一个预测模型.
主要成果:
- 确定了年龄,fPSA/tPSA比率,血清无机,血球蛋白,血清和LDL胆固醇作为PCa的独立预测因素.
- 更高的年龄,无机,血球蛋白和LDL胆固醇与PCa风险增加有关.
- 较低的fPSA/tPSA比率和血清与PCa风险降低有关.
结论:
- 60岁以上男性的PCa发生与BPH有关.
- 特定的血清生物标志物包括无机,血球蛋白,LDL胆固醇,fPSA/tPSA比率和血清与PCa有关.
- 这些发现可以为老年男性提供有针对性的查和管理.
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