胰岛素补充剂通过调节肠道微生物群来缓解奥克拉托克素A诱导的损伤
Jingjing Wang1, Mingzhen Jiang1, Xuhai Li1
1College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China.
Journal of agricultural and food chemistry
|August 13, 2024
概括
胰岛素通过调节肠道微生物群和增加有益的短链脂肪酸 (SCFA) 来保护免受甲毒素A (OTA) 的损伤. 这种益生菌策略提供了一种减轻菌毒素影响和支持脏健康的潜在途径.
科学领域:
- 动物科学动物科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 毒素A (OTA) 是一种致毒素,在动物中会导致损伤.
- 肠-轴和肠道微生物群在损伤中起作用.
- 胰岛素对OTA诱导的损伤的保护机制需要澄清.
研究的目的:
- 为了研究胰岛素对OTA诱导的脏损伤的影响.
- 阐明涉及肠道微生物群和短链脂肪酸 (SCFA) 的潜在机制.
主要方法:
- 被给予OTA和胰岛素两周.
- 分析包括肠道微生物群,SCFA含量和SCFA受体.
- 抗生素治疗和便微生物群移植证实了微生物群的作用.
主要成果:
- 胰岛素补充剂改变了肠道微生物群,增加了SCFA的产生.
- 胰岛素减轻了OTA诱导的损伤,显示出抗氧化和抗炎作用.
- 胰岛素减轻了NLRP3炎症酶激活和烧死.
结论:
- 胰岛素通过肠道微生物群调节,保护免受OTA诱导的损伤.
- 增加SCFA生产和减少炎症是关键机制.
- 像胰岛素这样的益生菌提供了与菌毒素相关的脏保护的有希望的策略.
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