对于耐火性声道过程粒瘤的内脉注射类固醇的治疗结果
Po-Jun Yu1, Wei-Chen Hung1, Chi-Te Wang1,2,3
1Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
概括
在耐火病例中,内射类固醇注射有效地减少了声过程颗粒瘤 (VPG) 的大小. 这种治疗为那些对保守疗法没有反应的患者提供了一个有希望的替代方案,显示出显著的体型减小,副作用最小.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 喉腔病理学 喉腔病理学
- 医学治疗学 医学治疗学
背景情况:
- 声道过程颗粒瘤 (VPG) 是一种慢性疾病,通常需要先进的治疗.
- 标准的保守疗法,如声道卫生和质子抑制剂,对于耐火性VPG可能是不够的.
- 现有的二线治疗方法,包括手术和肉毒素,具有不一致的结果.
研究的目的:
- 评估内伤性类固醇注射作为耐火性声道过程粒瘤的二线治疗的疗效.
- 评估内伤性类固醇注射对VPG减小大小的影响.
主要方法:
- 对23名VPG耐火3个月的质子抑制剂患者的回顾性审查.
- 患者每月接受一至三次的内外注射类固醇注射.
- 测量VPG大小与治疗前和治疗后的声长度相比.
主要成果:
- 显著减少VPG大小从27.74 ± 15.06到5.48 ± 8.95 (p < .001). 显著减少VPG大小从27.74 ± 15.06到5.48 ± 8.95 (p < .001).
- 23名患者中有15名 (65%) 实现了≥75%的体型减小.
- 与酒精使用和症状持续时间较长相关的反应较差;之前的输管治疗与更好的反应相关.
结论:
- 内射类固醇注射是耐火性VPG的可行和有前途的治疗方法.
- 这种治疗选择显示出显著的疗效,没有显著的不良影响.
- 对影响治疗反应的因素的进一步调查可能会优化患者的选择.
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