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Updated: Jun 17, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

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催化降解性C-N键交叉合在化和N-chloroamides之间

Yiting Luo1, Jiacan Yao1, Yunzhi He1

  • 1School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products; College of Modern Biomedical Industry, Kunming Medical University, 1168 Western Chunrong Road, Yuhua Street, Chenggong District, Kunming City, Yunnan 650500, P. R. China. xuchang@kmmu.edu.cn.

Organic & biomolecular chemistry
|August 13, 2024
PubMed
概括

一种新的催化反应直接从化和N-chloroamides中合成N-aryl乳酸盐和胺. 这种方法提供了温和的条件和广泛的适用性,产生生物活性分子的关键中间体.

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Preparation of Amines: Reduction of Amides and Nitriles01:13

Preparation of Amines: Reduction of Amides and Nitriles

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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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Nitriles are reduced to amines in the presence of strong reducing agents like lithium aluminum hydride through a typical nucleophilic acyl substitution. The reaction requires two equivalents of the reducing agent. The reducing agent acts as a source of hydride ions.
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