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在使用中链triglycerides进行新囊后,胡卜素的生物可访问性和Caco-2细胞吸收
Ziqi Li1, Siqiong Zhong2, Rachel E Kopec2,3
1Department of Food Science and Technology, The OH State University, Columbus, OH, USA.
Journal of dietary supplements
|August 13, 2024
概括
封装显著改善了氨酸和氨酸的吸收和肠道细胞吸收. 这表明,在未来的人类研究中,可增强胡卜素的生物可用性.
科学领域:
- 食品科学 食品科学 食品科学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 胡卜素是疏水的,限制了它们在以水为基础的食品中的使用.
- 封装增强了胡卜素的溶解性和潜在的生物可用性.
- 莱西丁和中链甘油三酸是常见的封装剂.
研究的目的:
- 评估莱西丁和中链甘油三糖体封装对胡卜素生物可访问性和肠道细胞吸收的影响.
- 为了比较液体 (VitaSperse®) 和粉末 (VitaDry®) 封装形式的氨酸和氨酸的疗效.
- 为了确定封装是否与未封装的形式相比改善了胡卜素的吸收.
主要方法:
- 利用体外消化模型测量微粒化胡卜素分数.
- 通过与Caco-2细胞化细胞分片来评估肠道细胞的吸收.
- 与未封装的对照进行了对比,封装的黄蛋白和素 (VitaSperse®和VitaDry®) 与未封装的对照进行了比较.
主要成果:
- 封装增加了阿斯塔桑的生物可访问性 2-2.4 倍和Caco-2 细胞吸收 ~ 2 倍.
- 封装增加了蛋白的生物可访问性3-5倍和Caco-2细胞吸收2.3倍.
- 在VitaSperse®和VitaDry®形式之间,Caco-2细胞吸收没有显著差异.
结论:
- 用莱西和中链甘油三糖的封装大大提高了黄蛋白和素的生物可访问性和肠道细胞吸收.
- 改善生物可访问性是从封装配方中增加胡卜素细胞吸收的主要驱动因素.
- 建议对人类进行进一步的研究,以确认这种封装方法增强了胡卜素的生物可用性.
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