多样性的子集中自愿的尼古丁消费和奖励 杂交的创始人菌株
Yumna Rahman1, Belle Buzzi1, Walker Rogers2
1Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Journal of psychopharmacology (Oxford, England)
|August 13, 2024
概括
尼古丁消耗在不同小鼠菌株之间有很大的差异,129S1/SvImJ小鼠的摄入量很高,A/J小鼠的摄入量很低. 这些消费模式是遗传的,为烟草依赖的遗传学提供了洞察力.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 尼古丁驱动烟草成,这是一个主要的全球健康问题.
- 了解影响尼古丁消费的遗传因素对于制定有效的戒烟策略至关重要.
研究的目的:
- 描述不同老鼠菌株和性别的尼古丁口服消费和偏好.
- 评估尼古丁度对摄入量和偏好的影响.
- 为了估计尼古丁消费的遗传变化.
主要方法:
- 在多样性异种 (DO) 创始菌株中利用了两瓶选择口服自我管理范式.
- 评估尼古丁摄入量,偏好和总体液体摄入量在不同度的尼古丁中.
- 使用有条件的位置偏好 (CPP) 测试来评估尼古丁的奖励和厌恶效应.
主要成果:
- 在尼古丁摄入量中观察到显著的菌株差异,其中129S1/SvImJ的摄入量最高,A/J的摄入量最低.
- 这些差异不能归因于味道敏感性 (昆因,糖).
- 与A/J小鼠不同的是,129S1/SvImJ小鼠对尼古丁有显著的条件偏好,与A/J小鼠不同.
结论:
- 尼古丁消费模式是遗传的,受基因型的影响在自愿自我管理中.
- 这些发现支持使用高度重组的DO小鼠进行未来的遗传研究,以确定影响尼古丁消费的新型基因和基因.
相关概念视频
Stimulants
178
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
178
Instinctive Drift
200
Instinctive drift refers to the tendency of animals to revert to their innate behaviors despite repeated reinforcement. Breland and Breland demonstrated this concept in an experiment with a raccoon. The raccoon was trained to pick up two coins and place them in a container in exchange for food. Initially, the raccoon learned to associate the coins with food, making them a conditioned stimulus or a substitute for food. However, over time, the raccoon became less willing to put the coins into the...
200


