用GnRHa治疗的女孩的生长模式,生长减速和相关预测因素:一项追溯纵向研究
Lixue Ouyang1,2, You Lu1,2, Liangkang Lin1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal of pediatric endocrinology & metabolism : JPEM
|August 13, 2024
概括
在性腺激素释放激素激动剂 (GnRHa) 治疗期间的生长减速在中部早期青春期 (CPP) 和早期青春期 (EFP) 女孩之间有所不同. 骨年龄 (BA) 预测生长减速,建议在EFP治疗时谨慎使用.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 增长和发展 增长和发展
背景情况:
- 中部早期青春期 (CPP) 和早期青春期 (EFP) 涉及青春期的早期发作.
- 淋巴激素释放激素激活剂 (GnRHa) 疗法被用于通过抑制青春期来管理这些疾病.
- 在GnRHa治疗期间了解生长模式对于优化结果至关重要.
研究的目的:
- 分析接受GnRHa治疗的CPP和EFP女孩的身高增长模式.
- 为了确定在GnRHa治疗期间显著增长减速的发生率.
- 确定这些患者群体中增长减速的预测因素.
主要方法:
- 对99名患有CPP和47名患有EFP的接受GnRHa治疗的女孩进行了回顾性分析.
- 在治疗的第一年和第二年计算增长减速的发生率.
- 多变量后勤回归和ROC曲线分析以确定预测因素.
主要成果:
- 增长速度 (GV) 最初下降,然后恢复,CPP组的恢复更大.
- 在CPP和EFP组之间,第一年增长减速发生率没有显著差异.
- 与EFP组 (76.92%) 相比,CPP组的第二年增长放缓明显较低 (42.86%).
- 骨年龄 (BA) 是增长减速的独立预测指标 (OR=2.264),截止值为11.05年.
结论:
- 在GNRHa治疗期间,GV动态有所不同.
- 与CPP管理相比,GnRHa治疗需要在EFP中更加谨慎.
- 骨质年龄是识别女孩在GnRHa治疗期间生长减速风险的有价值的预测指标.
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