全球老年人群中多药的流行:系统性审查和元分析
Zeyu Wang1, Tangyi Liu1, Qiaoyu Su1,2
1Department of Gastroenterology, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University Xian, Xi'An, Shaanxi, China.
多药性 (PP),即使用多种药物,影响全球近40%的老年人. 这种患病率在70岁以上的人群中,在发达地区和养老院中更高.
科学领域:
- 老年学是一门学科.
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 多药性 (PP) 是老年人群的一个重要问题,与不良健康结果和医疗保健成本的增加有关.
- 了解PP的全球流行率和相关因素对于有效的医疗保健管理至关重要.
研究的目的:
- 进行系统性审查和元分析,以确定老年人中多药性 (PP) 的全球流行情况.
- 确定与这一人口群体中更高PP流行率相关的因素.
主要方法:
- 搜索了主要的数据库 (PubMed,科学网,Cochrane,Embase) 来查找2022年5月为止60岁以上的个人对PP的观察性研究.
- 定义PP是使用五种或更多药物;超多药 (HPP) 是十种或更多.
- 采用随机效应模型进行聚合流行率估计和元回归以确定相关因素.
主要成果:
- 分析了122项涉及超过5700万个人的研究.
- 全球PP的流行率为39.1%,HPP为13.3%.
- 患病率因地区而异 (欧洲:45.8%,北美:40.8%,亚洲:29.0%) 并且在70岁以上的个人和居住在养老院的人中更高.
结论:
- 全球近40%的老年人体验过多药 (PP).
- 在70岁及以上的个人,发达地区 (欧洲,北美) 和养老院居民中观察到更高的PP患病率.
- 需要有针对性的干预措施来减轻与老年人不适当的PP相关的风险.
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