怀孕期间母亲的维生素D状况和婴儿的肠道微生物群:一个前性队列研究
Qiying Song1, Yao Li2, Tao Zhou3
1Department of Child Healthcare, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, China.
Frontiers in nutrition
|August 13, 2024
概括
母亲的维生素D水平显著影响婴儿肠道微生物群的发展. 母亲的维生素D不足与6个月以下婴儿的肠道微生物多样性和功能变化有关.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 儿科 儿科 儿科
背景情况:
- 母亲的维生素D状况对于婴儿的健康至关重要.
- 早期的肠道微生物组在免疫发育和整体福祉中起着至关重要的作用.
- 了解母亲营养和婴儿肠道微生物群之间的相互作用对于公共卫生至关重要.
研究的目的:
- 调查中国人群中母体血清25-氧维生素D[25(OH) D]水平与婴儿肠道微生物群组成之间的关联.
- 评估母亲的维生素D状况对1至6个月大的后代肠道微生物群的动态变化的影响.
主要方法:
- 长度研究87个母婴双,按母亲的维生素D充足程度分类.
- 从1个月和6个月大的婴儿收集的便样本用于16S rRNA基因测序.
- 分析包括用于α多样性的混合效应模型,用于β多样性的PERMANOVA,以及用于差异性种群丰度的LDA.
主要成果:
- 维生素D缺乏的母亲的婴儿在6个月时显示出明显较低的α多样性 (Pielou的均性,Shannon多样性),但在1个月时没有.
- 在1个月和6个月的两组之间观察到肠道微生物群组成的显著差异.
- 在维生素D缺乏组中,与氨基酸生物合成,粉降解和纯氨酸核酸生物合成相关的途径的丰富性被注意到.
结论:
- 母亲的维生素D状况是早期肠道微生物群发育的关键决定因素.
- 这些发现强调了适当的母体维生素D水平对于塑造健康的婴儿肠道微生物组的重要性.
- 针对母亲维生素D的干预措施可能会影响婴儿肠道微生物生态.
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