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通过新的氧化途径到N-arylpyridoindazolium盐

Oleg A Levitskiy¹, Yuri K Grishin¹, Tatiana V Magdesieva¹

¹Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow, 119234, Russia.

Beilstein journal of organic chemistry

|August 13, 2024

概括

一种新的方法通过直接氧化二甲胺前体来合成N-arylpyridoindazolium盐. 这种简单的方法提供了使用化学氧化剂或电化学的后期功能化策略.

科学领域:

有机合成有机合成
药用化学医学化学
异环化学异环化学

背景情况:

N-arylpyridoindazolium盐是重要的异环化合物,在药物化学中具有潜在的应用.
现有的合成路线可能涉及多个步骤或恶劣的条件,限制其实用性.
晚期功能化策略对于高效的分子合成是非常理想的.

研究的目的:

为N-arylpyridoindazolium盐开发一种新且易于合成的方法.
探索直接合成的化学和电化学氧化方法.
使用易于获得的前体建立后期功能化路线.

主要方法:

使用 bis ((trifluoroacetoxy) iodobenzene 的方法直接氧化奥托-皮里丁替代的迪亚利胺.
在温和条件下通过潜在静态氧化进行电化学合成.
使用易于获取的 орто-pyridyl-substituted diarylamines作为起始材料.

主要成果:

通过直接氧化实现了N-arylpyridoindazolium盐的成功合成.
电化学合成证明了温和的反应条件,只需要电流.
化学和电化学方法都代表了高效的后期功能化途径.

结论:

已经建立了一种新且易于合成N-arylpyridoindazolium盐的方法.
电化学合成提供了一个温和条件的环保替代方案.
开发的方法为有机合成的后期功能化提供了有价值的工具.

关键词:

阳极氧化过程中的阳极氧化.迪亚利胺是什么?电化学循环化的电化学循环.皮里多扎盐的盐.可逆环闭合闭合可以逆转.

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