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益生菌发酵发芽谷物复合体对睡眠剥夺小鼠神经递质和睡眠质量的保护作用
Jiahua Cheng1, Qiqi Wu1, Rui Sun1,2
1Yan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, Yan'an, China.
Frontiers in microbiology
|August 13, 2024
概括
来自发芽谷物的益生菌发酵产品显著改善了睡眠,并减少了睡眠不足小鼠的焦虑. 这些天然产品可能通过调节神经递质和肠道健康来开发失眠治疗的新方法.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 睡眠不足是一个重要的健康问题,有效治疗方法有限.
- 发芽的谷物富含生物活性化合物,具有潜在的健康益处.
- 益生菌发酵可以提高营养素的生物可用性和有效性.
研究的目的:
- 研究芽谷物的益生菌发酵产品在减轻小鼠睡眠剥夺引起的认知和情绪障碍方面的疗效.
- 阐明涉及神经递质调节,炎症调节和肠道微生物群变化的潜在机制.
- 为开发天然产品作为治疗失眠的方法提供科学基础.
主要方法:
- 使用甲氨酸 (PCPA) 诱导睡眠剥夺.
- 用ELISA和HPLC分析发酵产品的氨酸 (GABA) 和L-theanine含量.
- 评估了行为测试 (开放场测试),神经递质和细胞因子水平 (ELISA),肠道微生物群组成 (16S rRNA测序) 和短链脂肪酸概况 (LC-MS/MS).
主要成果:
- 在接受PCPA治疗的小鼠中,发酵产品显著增加了睡眠时间和减少了类似焦虑的行为.
- 下丘脑中的关键神经递质 (血清激素,GABA,谷氨酸) 和血清中的抗炎标志物得到了有利的调节.
- 干预后观察到肠道微生物群结构的显著改善和短链脂肪酸水平的增加.
结论:
- 发芽谷物的益生菌发酵产品在改善睡眠剥夺和相关行为缺陷方面显示出显著的潜力.
- 观察到的好处很可能是由中央神经递质系统的调节,系统性炎症的减少和肠-大脑轴的调节介导的.
- 这些发现支持发芽谷物衍生益生菌的发展,作为一种有希望的自然治疗失眠策略.
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