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相关概念视频

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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相关实验视频

Updated: Jun 17, 2025

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
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Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

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内腺扩散:一种特殊的病理特征.

Yubi Zhang1, Yu Deng1, Meng Zhou1

  • 1Department of Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in oncology
|August 13, 2024
PubMed
概括

甲状腺癌的内腺扩散表明更具侵略性的行为和更高的转移风险. 与此特征相关的特定蛋白质表达可能指导未来的向疗法.

关键词:
在BRAF V600E突变中.腺体内传播 腺体内传播淋巴结转移是淋巴结的转移.乳头状甲状腺癌 (PTC)甲状腺癌 (TC) 是一种

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科学领域:

  • 在瘤学瘤学.
  • 病理学 病理学 病理学

背景情况:

  • 内腺扩散是甲状腺癌的一个关键病理特征.
  • 它的生物特征和预后影响尚未完全理解.

研究的目的:

  • 综合审查甲状腺癌中腺内传播的生物行为.
  • 探索相关的蛋白质表达和诊断方法.

主要方法:

  • 对甲状腺癌与内腺扩散的回顾性研究的审查.
  • 对蛋白质表达的免疫组织化学数据的分析.
  • 对辅助诊断技术的评估.

主要成果:

  • 甲状腺癌与内腺扩散的甲状腺癌显示淋巴结,囊和血管入侵增加.
  • 像FKBP5,CENPF和KIF11这样的蛋白质的异常表达与预后不佳相关.
  • 超声波,细针吸收和基因检测有助于鉴定.

结论:

  • 内腺扩散意味着甲状腺癌生物学上更具侵略性.
  • 特定的蛋白质生物标志物可能为未来的疗法提供点.
  • 准确的识别有助于主动治疗和监测.