相关实验视频

Updated: Jun 17, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

机器人:瘤免疫微环境研究的新前沿

Yujia Yang^1,2, Jinlei Cui¹, Yajie Kong^1,2

¹Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Hebei Medical University, Immunology Department of Hebei Medical University, Shijiazhuang, China.

Frontiers in immunology

|August 13, 2024

概括

瘤器官提供了一个3D模型,比传统的2D培养更好地模仿患者的瘤. 这些先进的模型对于了解瘤微环境和改进癌症免疫治疗策略至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

瘤微环境 (TME) 显著影响癌症的进展和治疗反应.
传统的二维细胞培养无法捕捉患者瘤的体内异质性和复杂性.
免疫疗法彻底改变了癌症治疗,需要更好的临床前模型.

研究的目的:

审查有机体在理解瘤免疫微环境中的作用.
讨论器官在免疫治疗研究和建模中的应用.
探索瘤器官在精密医学中的翻译潜力.

主要方法:

机体模型是3D体外系统,可以在体内复制组织特性.
瘤器官是从患者的瘤细胞中提取的,结合了 stromal 和免疫成分.
这些模型保留了瘤异质性和关键的TME特征.

主要成果:

有机器人回顾了人类疾病的遗传和物理相似性.
它们可以部分重建复杂的瘤结构,提供比2D模型更准确的表示.
有机器人越来越多地用于癌症研究,药物开发和疾病建模.

结论:

器官类药物作为研究瘤微环境及其对免疫疗法的影响的强大工具.
瘤有机体促进了免疫瘤学研究和免疫治疗建模方面的进步.
这些模型对个性化医疗和量身定制的癌症治疗具有重大前景.

关键词:

癌症癌症癌症癌症癌症免疫疗法免疫疗法这是一种有机体的有机物.精准医学是一门精准医学.瘤微环境是一个微环境.

更多相关视频

Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation

Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation

Published on: September 6, 2024

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...