压电双层-铁分层双氧化物纳米片与瘤微环境响应强化压催化疗法
Shaohua Liu1,2,3, Jianchun Bao1, Boshi Tian2,3
1Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, P. R. China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 13, 2024
概括
可生物降解的铁层双氧化物 (NiFe-LDH) 纳米片通过在超声波下产生反应性氧物种来增强压催化疗法 (PCT). 这种新的方法还诱导铁亡,提供了一个有前途的新癌症治疗策略.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 使用二维材料的皮埃佐催化疗法 (PCT) 是一种有前途的非侵入性癌症治疗方法.
- 2D纳米材料在PCT中产生反应性氧物种 (ROS) 的机制需要进一步研究.
研究的目的:
- 开发和研究可生物降解的压电二维双层-铁层双氧化物 (NiFe-LDH) 纳米片,用于增强PCT和铁.
- 阐明用于ROS生成的底层压催化机制.
主要方法:
- 可生物降解的压电二维双层NiFe-LDH纳米薄膜 (厚度约1.86nm) 的合成.
- 应用超声波辐射来诱导压催化和ROS生成 (超氧化离子激素和单片氧).
- 评估NiFe-LDH的瘤微环境 (TME) 响应型过氧化酶类和谷氨耗尽活动.
主要成果:
- 通过内置的电场和刺激效应,NiFe-LDH纳米片在超声波下通过内置的电场和刺激效应证明了高效的超氧离子激素和单片氧的产生.
- 该材料表现出对TME敏感的POD类活性和GSH减肥能力,增强氧化应激.
- 超声波触发的NiFe-LDH有效地诱导了瘤细胞中的铁亡.
结论:
- 可生物降解的NiFe-LDH纳米片作为有效的压电半导体声敏剂,用于增强PCT和铁灭菌诱导.
- 这项研究提供了对用于癌症治疗的LDHs中的压催化机制的全面了解.
- 这些发现为在癌症治疗中应用LDH和其他2D材料提供了有价值的参考资料.
更多相关视频
10:39Preparation of ZnO Nanorod/Graphene/ZnO Nanorod Epitaxial Double Heterostructure for Piezoelectrical Nanogenerator by Using Preheating Hydrothermal
Published on: January 15, 2016
12.5K
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
相关概念视频
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...