腹部脂肪组织摄取葡萄糖对大脑衰老的影响
Weizhao Lu1, Yanhua Duan2, Kun Li2
1School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.
概括
内脏脂肪组织的葡萄糖吸收减缓了大脑的衰老. 皮下脂肪组织的葡萄糖吸收有利于瘦个体,但在女性和超重/肥胖个体中加速衰老.
科学领域:
- 代谢健康和神经科学
- 衰老的研究研究.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 腹部脂肪组织 (AT) 积累与负面的大脑健康结果有关.
- 了解AT葡萄糖代谢在大脑衰老中的作用至关重要.
研究的目的:
- 调查腹部皮下和内脏AT葡萄糖吸收对大脑衰老的影响.
- 为了确定AT葡萄糖代谢是否影响大脑年龄delta.
主要方法:
- 在325名参与者中利用全身正子发射断层扫描 (PET) 扫描.
- 使用支持向量回归模型对227名参与者进行训练,并对98名参与者进行测试,估计了大脑年龄.
- 通过线性回归分析了腹部AT葡萄糖吸收 (SAT/VAT) 和大脑年龄三角形之间的关联.
主要成果:
- 内脂肪组织 (VAT) 葡萄糖吸收增加与所有亚组的负脑年龄三角函数相关.
- 较高的皮下脂肪组织 (SAT) 葡萄糖吸收与瘦个体的负脑年龄三角形有关.
- 相反,较高的SAT葡萄糖摄入量显示出女性和超重/肥胖个体的大脑年龄三角形的积极趋势.
结论:
- 在腹部内脏脂肪组织 (VAT) 中增加葡萄糖的吸收似乎减缓了大脑的衰老.
- 皮下脂肪组织 (SAT) 的葡萄糖吸收可能不会给大脑带来衰老的好处,除了瘦身的人.
- 摄取SAT葡萄糖的差异性影响凸显了它与不同人群中大脑衰老的复杂关系.
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