基于个性化护理包的新型干预措施,以减少移植接受者的感染.
Lucía de Jorge-Huerta1, José Tiago Silva1, Mario Fernández-Ruiz1,2,3
1Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.
概括
一个个性化的感染预防包显著减少了移植接受者的感染. 这一策略改善了对预防措施的遵守,降低了感染率和移植后12个月内住院的情况.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 感染是移植 (KT) 后的一个重要并发症.
- 基于证据的实践捆绑是改善临床结果的公认策略.
- 这项研究调查了个性化的捆绑,以减少KT后的第一年感染发病率.
研究的目的:
- 为了评估个性化感染预防捆绑在脏移植接受者的有效性.
- 评估包对遵守预防措施的影响.
- 确定对感染率,住院和严重感染在KT.后12个月内的影响.
主要方法:
- 一项前性单中心队列研究将148名接受个性化感染预防策略的患者与159名患者的预防干预队列进行了比较.
- 干预包包括免疫审查,感染风险评估,潜伏结核感染 (LTBI) 查,抗菌预防和免疫评估.
- 在移植后的30天访问中,提供了个性化的建议.
主要成果:
- 干预组对接种疫苗,LTBI查和补充剂的遵守程度更高 (p <.001).
- 在干预队列中观察到较低的一年感染率 (42.6%与57.9%,p=.037) 和与感染有关的住院 (17.6%与32.1%,p=.003).
- 严重细菌感染的发生率也减少了;在移植排斥或死亡率上没有发现差异.
结论:
- 一个多方面的干预,包括一组基于证据的实践,改善了对预防措施的坚持.
- 这种个性化方法与移植后12个月内感染率降低有关.
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