与Candida auris血流感染的不良临床和微生物学结果相关的因素:多中心回顾性队列研究
Adriana Jimenez1,2, Rossana Rosa3, Samantha Ayoub4
1University of Miami Health System, Miami, Florida, USA.
概括
血流感染 (BSI) 是一个日益增长的全球威胁. 皮特细菌血症得分预测死亡率,而血液透析增加了这些患者不良结果的风险.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 公共卫生 公共卫生
背景情况:
- 黄是一种新兴的多药耐药性真菌病原体,引起了全球健康的重大关注.
- 殖民和侵入性感染的发病率越来越高,需要了解临床结果.
- 关于在Candida auris血流感染 (BSI) 中预测不良结果的因素的数据有限.
研究的目的:
- 为了确定与死亡率和血液培养清除相关的临床因素,在患有Candida auris BSI.的患者.
- 分析多中心回顾性队列中不良结果的风险因素.
主要方法:
- 在两家美国医疗机构对187名患有Candida auris BSI的患者进行了回顾性队列研究.
- 数据收集包括人口,临床和微生物特征.
- 使用多变量逻辑回归模型来评估死亡率和血液培养清除风险因素.
主要成果:
- 该队列包括187名患者,54.6%的患者经历了全因死亡,66.9%的患者实现了血液培养清除.
- 较高的皮特细菌血症得分与死亡率的增加显著相关 (或每点增加1.19).
- 血液透析与微生物清除率降低 (OR 0.15) 和死亡率增加 (OR 3.08) 有关.
结论:
- 皮特细菌病评分可以识别患有Candida auris BSI的患者死亡风险较高.
- 针对血液透析患者的针对性感染预防策略对于减轻不良结果至关重要.
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