双结合区域异构体的分子间组装产生了高性能AIE探头
Ziwei Xu1, Bingling Zhang1, Shusen Chen2
1Department of State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Small (Weinheim an der Bergstrasse, Germany)
|August 13, 2024
概括
本研究介绍了一个区域异构体策略,通过控制分子相互作用来制造先进的聚合诱导排放光原体 (AIEgens). 整形异构体显示出优异的AIE活性,为更明亮的AIE基因和增强的生物成像应用铺平了道路.
科学领域:
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
- 超分子化学 超分子化学
背景情况:
- 聚合诱导排放发光剂 (AIEgens) 对先进的光学材料至关重要.
- 通过regio-isomerism设计具有可调节性质的AIEgens是一个新兴领域,机理理解有限.
- 控制固态中的分子间相互作用是提高AIE特性的关键.
研究的目的:
- 为设计具有增强聚合诱导排放 (AIE) 活动的新型AIEgens制定一个区域异构体战略.
- 根据区域异构和分子间相互作用,阐明控制AIE性能的基本机制.
- 验证该战略的多功能性,并探索开发的AIEgens在生物成像应用中的潜力.
主要方法:
- 区域异构体AIE基因 (正体和副体异构体) 的合成和表征.
- 使用DFT计算和单晶X射线衍射分析,研究结构-属性关系.
- 对合成化合物及其衍生物的AIE特性和生物成像能力的评估.
主要成果:
- 整形区域同位素 (DCM-O3-O7) 与偏方同位素 (DCM-P6) 相比,显著增强了AIE活性.
- 双键 (C─H∙∙∙π和C─H∙∙∙N) 被确定为促进二聚体,四聚体和1D超分子结构的关键相互作用,限制分子内运动和增强光.
- 该策略与其他供体接受体光体得到了验证,从而产生了高效的生物成像探针,包括溶酶体向,细胞膜向和体内瘤成像剂.
结论:
- 区域同位素策略提供了一种通用和有效的方法,通过精确控制分子间相互作用来设计明亮的AIEgens.
- 了解双键和替代剂大小的作用对于优化AIE性能至关重要.
- 开发的AIEgens对各种生物成像应用具有很大的前景,表现出高准特异性和成像准确性.
相关概念视频
¹H NMR: Long-Range Coupling
1.7K
The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...
1.7K
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
8.4K
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
8.4K
Stereoisomerism
11.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
11.8K
Hydrogen Bonds
8.2K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
8.2K
¹H NMR: Complex Splitting
1.3K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.3K
Hybridization of Atomic Orbitals II
31.9K
sp3d and sp3d 2 Hybridization
31.9K


