先进的纳米技术方法,以有效的交付的鲁:一个更新的审查
Keshav Bansal1, Hemant Bhati1, Vanshita Singh1
1Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India.
Pharmaceutical nanotechnology
|August 13, 2024
概括
鲁是一种植物性多,提供了许多健康益处,但面临着交付挑战. 纳米配方显示出增强 rutin 的承诺.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 纳米技术 纳米技术
背景情况:
- 聚醇,包括在麦和类植物中发现的鲁丁,表现出多样化的生物活动.
- 鲁丁具有抗菌,抗炎,抗糖尿病,抗癌和神经保护性质等.
- 由于水溶性差,氧化敏感性和缓慢溶解,素的治疗用途受到阻碍.
研究的目的:
- 审查针对性治疗的有效的鲁丁纳米配方.
- 讨论鲁丁纳米载体的临床证据,当前状态和未来的机会.
- 探索提高 rutin 的生物活性和治疗适用性的策略.
主要方法:
- 关于鲁丁纳米配方研究的文献综述.
- 对路丁纳米载体的临床前和临床数据的分析.
- 综合关于配方策略和治疗结果的信息.
主要成果:
- 已经开发出各种纳米载体系统来克服rutin的局限性.
- 纳米配方提高了鲁丁的溶解性,稳定性和生物可用性.
- 新出现的证据支持素纳米载体在治疗各种健康疾病方面的潜力.
结论:
- 常规纳米配方代表了一种有希望的方法来增强其治疗疗效.
- 需要进一步的临床前和临床研究,才能充分发挥鲁丁纳米载体的潜力.
- 有针对性的输送系统可以释放rutin的全部药用潜力.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
330
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
330
01:18Drug Delivery: Enteral Route
406
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
406
01:16Drug Delivery: Overview
279
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
279
01:09Methods for Studying Drug Absorption: In situ
216
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
216