在停止长期0.01%的近视阿特罗平治疗期间和之后的冠状腺变化 控制近视
Samantha Sze-Yee Lee1,2, Gareth Lingham1,3,4, Antony Clark1,5,6
1University of Western Australia, Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), Perth, Western Australia, Australia.
Investigative ophthalmology & visual science
|August 13, 2024
概括
用于近视控制的低度阿特罗宾眼药在治疗期间没有改变胸膜厚度. 然而,停止这些滴滴可能会扰乱儿童的正常胆管厚.
科学领域:
- 眼科医生 眼科 眼科
- 儿科眼科 儿科眼科
- 近视控制研究研究近视.
背景情况:
- 控制近视的策略对于预防视力障碍至关重要.
- 近视控制干预措施对眼部结构的长期影响需要进一步研究.
- 冠状腺变化与折射发育和近视的进展有关.
研究的目的:
- 在停止使用低度阿特罗宾眼药用于近视控制期间和之后,评估胸膜厚度 (ChT) 和胸膜血管度指数 (CVI).
- 评估0.01%的氨酸停止对儿童胸腔发育的影响.
- 为了比较治疗停止后,在阿特罗宾和安慰剂组之间胆道变化.
主要方法:
- 一项为期2年的随机对照试验,涉及153名患有渐进近视的儿童 (6-16岁),比较了0.01%的阿特罗宾与安慰剂.
- 接下来的1年的洗期没有使用眼滴.
- 光学连贯性断层扫描 (OCT) 成像测量在基线,治疗结束和洗结束时的亚叶胆道厚度 (ChT) 和胆道血管度指数 (CVI).
主要成果:
- 在2年的治疗阶段,在阿特罗平和安慰剂组之间没有显著的差异.
- 在1年的洗过程中,安慰剂组显示状腺厚持续,而阿特罗平组的状腺厚保持稳定.
- 冠状腺厚与轴眼生长控制相关;然而,在快速进展的儿童中,阿特罗平对冠状腺厚的影响在停止后没有持续.
- 在治疗期间,胆道血管度指数下降,但在安慰剂组停止治疗后增加.
结论:
- 虽然与安慰剂相比,0.01%的阿特罗宾在治疗期间不会对胸膜厚度产生差异性影响,但其突然停止可能会干扰儿童的正常胸膜发育.
- 停止长期使用低度的阿特罗宾可能会导致状腺适应的改变.
- 需要进一步的研究,以了解氨酸停止对眼睛发育和折射误差进展的长期影响.
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