涂层微气泡的稳定腔层建模:一个整合光滑散射粒子动态和雷利-普莱塞特方程的框架
1Université Paris Cité, CNRS, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
The Journal of chemical physics
|August 13, 2024
概括
来自化微泡的声学微流产生高剪切应力,这对于药物输送至关重要. 我们的新型模拟方法揭示了微流动力学和高剪切应力水平,影响细胞膜孔隙形成.
科学领域:
- 生物物理学的生物物理.
- 流体动力学 流体动力学
- 声学 声学 在声学方面
背景情况:
- 涂层微气泡对于药物和基因传递等医疗应用至关重要.
- 来自化气泡的声学微流会诱导细胞膜的剪切应力.
研究的目的:
- 开发一种用于微气泡化的新型模拟方法.
- 在微秒和微米尺度上研究微流和剪切应力动态.
主要方法:
- 结合光滑散射粒子动力学 (SDPD) 用于流体动力学.
- 雷利-普莱塞特式方程的数值建模用于泡动力学.
- 模拟了一个1.5μm涂层的微气泡,由2MHz超声波在500kPa下驱动.
主要成果:
- 观测到在微气泡周围的高速微流在微秒内.
- 揭示了附近表面的高剪切应力水平 (数千帕斯卡尔).
- 从相反的流体层运动中产生的经过证明的微流.
结论:
- 这种新型的模拟准确地捕捉了微气泡化动态.
- 模拟的剪切应力水平明显超过以前的理论模型.
- 结果提供了关于泡腔化诱导的细胞膜孔形成的见解.
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