相关实验视频
Updated: Jul 6, 2026
08:15
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
12.1K
基于多糖的微针系统的进步,用于治疗眼部疾病
Qingdong Bao1,2,3, Xiaoting Zhang4, Zhankun Hao3
1State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, 266071, People's Republic of China.
Nano-micro letters
|August 13, 2024
概括
基于多糖的微针为眼科药物输送提供了一种新的方法,克服了眼睛的障碍. 这篇评论详细介绍了它们的设计,制造以及改善眼睛治疗的潜力.
科学领域:
- 眼科和生物材料科学 眼科和生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 眼睛独特的生理学为有效的药物输送带来了重大挑战.
- 传统的眼科药物输送方法往往导致治疗结果不理想,患者遵守不良.
研究的目的:
- 提供基于多糖的微针 (PSMNs) 用于眼科药物输送的全面审查.
- 分析聚糖化学和微针技术的整合,以改善眼部药物输送.
主要方法:
- 批判性地检查PSMN设计原则和制造工艺.
- 分析PSMN制造中的挑战,重点关注患者的舒适性和合规性.
- 审查最近的进展和PSMNs在研究和临床环境中的性能数据.
主要成果:
- PSMN代表了一种有前途的战略,可以克服眼障碍并提高药物的生物可用性.
- 制造方法正在完善,以提高患者的体验和治疗的坚持.
- 新兴的研究和临床数据表明,PSMNs对各种眼科疾病的潜在疗效.
结论:
- 眼科药物输送系统提供了眼科药物输送的转型解决方案,解决了传统方法的局限性.
- 对监管框架和市场障碍的进一步研究对于临床和商业成功至关重要.
- 本次审查强调了PSMN在推进眼疗法的重大潜力.
相关概念视频
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...